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Periodic perturbations in Shaker K(+) channel gating kinetics by deletions in the S3–S4 linker

Upon depolarization positive charges contained in the transmembrane segment S4 of voltage-dependent channels are displaced from the cytoplasmic to the external milieu. This charge movement leads to channel opening. In Shaker K(+) channels four positively charged arginines in the S4 domain are transf...

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Detalhes bibliográficos
Main Authors: Gonzalez, Carlos, Rosenman, Eduardo, Bezanilla, Francisco, Alvarez, Osvaldo, Latorre, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC55501/
https://ncbi.nlm.nih.gov/pubmed/11493701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171306298
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