Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development

The molecular mechanism of memory formation remains a mystery. Here, we show that TERT, the catalytic subunit of telomerase, gene knockout (Tert(−/−)) causes extremely poor ability in spatial memory formation. Knockdown of TERT in the dentate gyrus of adult hippocampus impairs spatial memory process...

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Podrobná bibliografie
Vydáno v:Stem Cell Reports
Hlavní autoři: Zhou, Qi-Gang, Liu, Meng-Ying, Lee, Han-Woong, Ishikawa, Fuyuki, Devkota, Sushil, Shen, Xin-Ru, Jin, Xin, Wu, Hai-Yin, Liu, Zhigang, Liu, Xiao, Jin, Xun, Zhou, Hai-Hui, Ro, Eun Jeoung, Zhang, Jing, Zhang, Yu, Lin, Yu-Hui, Suh, Hoonkyo, Zhu, Dong-Ya
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550029/
https://ncbi.nlm.nih.gov/pubmed/28757168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.06.014
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