Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes

Modulation of transcription, either synthetic activation or repression, via dCas9-fusion proteins is a relatively new methodology with the potential to facilitate high-throughput up- or downregulation studies of gene function. Genetic studies of neurodevelopmental disorders have identified a growing...

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Pubblicato in:Stem Cell Reports
Autori principali: Ho, Seok-Man, Hartley, Brigham J., Flaherty, Erin, Rajarajan, Prashanth, Abdelaal, Rawan, Obiorah, Ifeanyi, Barretto, Natalie, Muhammad, Hamza, Phatnani, Hemali P., Akbarian, Schahram, Brennand, Kristen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550013/
https://ncbi.nlm.nih.gov/pubmed/28757163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.06.012
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