MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons

The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact on neurons of such expression differences has yet to be...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Beevers, Joel E., Lai, Mang Ching, Collins, Emma, Booth, Heather D.E., Zambon, Federico, Parkkinen, Laura, Vowles, Jane, Cowley, Sally A., Wade-Martins, Richard, Caffrey, Tara M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549835/
https://ncbi.nlm.nih.gov/pubmed/28689993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.06.005
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