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Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB

The nonstructural protein 5A (NS5A) encoded by the human hepatitis C virus RNA genome is shown here to induce the activation of NF-κB and STAT-3 transcription factors from its cytoplasmic residence via oxidative stress. NS5A causes the disturbance of intracellular calcium. Ca(2+) signaling triggers...

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Detaylı Bibliyografya
Asıl Yazarlar: Gong, Guozhong, Waris, Gulam, Tanveer, Rasheeda, Siddiqui, Aleem
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2001
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC55498/
https://ncbi.nlm.nih.gov/pubmed/11481452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171311298
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