Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice

Mammalian genomes harbor millions of retrotransposon copies, some of which are transpositionally active. In mouse prospermatogonia, PIWI-interacting small RNAs (piRNAs) combat retrotransposon activity to maintain the genomic integrity. The piRNA system destroys retrotransposon-derived RNAs and guide...

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Pubblicato in:PLoS Genet
Autori principali: Inoue, Kota, Ichiyanagi, Kenji, Fukuda, Kei, Glinka, Michael, Sasaki, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549759/
https://ncbi.nlm.nih.gov/pubmed/28749988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006926
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