Regenerating Family Member 4 (Reg4) Enhances 5-Fluorouracil Resistance of Gastric Cancer Through Activating MAPK/Erk/Bim Signaling Pathway

BACKGROUND: Reg4, a member of the Reg multigene family, is highly upregulated in many gastrointestinal cancers including gastric cancer (GC). The enhanced expression of Reg4 is associated with the resistance of GC to 5-fluorouracil (5-FU), while the underlying mechanism is not clear. The aim of the...

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Detalhes bibliográficos
Publicado no:Med Sci Monit
Main Authors: Jin, Jiaoyue, Lv, Hang, Wu, Junzhou, Li, Dan, Chen, Kaiyan, Zhang, Fanrong, Han, Jing, Feng, Jianguo, Zhang, Nan, Yu, Herbert, Su, Dan, Ying, Lisha
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2017
Assuntos:
Lab/In Vitro Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549713/
https://ncbi.nlm.nih.gov/pubmed/28759561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.903134
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