Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells

Overexpression of the zinc enzyme carbonic anhydrase (CA; EC 4.2.1.1) XII is observed in certain human cancers. This bitopic membrane protein contains an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. We have determined the three-...

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Autors principals: Whittington, Douglas A., Waheed, Abdul, Ulmasov, Barbara, Shah, Gul N., Grubb, Jeffrey H., Sly, William S., Christianson, David W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC55489/
https://ncbi.nlm.nih.gov/pubmed/11493685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161301298
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