HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol

Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry signi...

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Main Authors: Hung, Shuen-Iu, Chung, Wen-Hung, Liou, Lieh-Bang, Chu, Chen-Chung, Lin, Marie, Huang, Hsien-Ping, Lin, Yen-Ling, Lan, Joung-Liang, Yang, Li-Cheng, Hong, Hong-Shang, Chen, Ming-Jing, Lai, Ping-Chin, Wu, Mai-Szu, Chu, Chia-Yu, Wang, Kuo-Hsien, Chen, Chien-Hsiun, Fann, Cathy S. J., Wu, Jer-Yuarn, Chen, Yuan-Tsong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC554812/
https://ncbi.nlm.nih.gov/pubmed/15743917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409500102
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