Design and Synthesis of 2- and 3-Substituted-3-phenylpropyl Analogs of 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: Role of Amino, Fluoro, Hydroxyl, Methoxyl, Methyl, Methylene, and Oxo Substituents on Affinity for the Dopamine and Serotonin Transporters

In our search for potential cocaine-abuse therapeutic agents, novel derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909, 1) and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935, 2) with various substituents in positions C2 and C3 of the...

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Publicado no:J Med Chem
Main Authors: Hsin, Ling-Wei, Chang, Li-Te, Rothman, Richard B., Dersch, Christina M., Jacobson, Arthur E., Rice, Kenner C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548119/
https://ncbi.nlm.nih.gov/pubmed/18393401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701270n
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