WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis

The tyrosine kinase WEE1 controls the timing of entry into mitosis in eukaryotes and its genetic deletion leads to pre-implantation lethality in mice. Here, we show that besides the premature mitotic entry phenotype, Wee1 mutant murine cells fail to complete mitosis properly and exhibit several addi...

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Bibliographic Details
Published in:	Oncogene
Main Authors:	Vassilopoulos, A, Tominaga, Y, Kim, H-Seok, Lahusen, T, Li, B, Yu, H, Gius, D, Deng, C-X
Format:	Artigo
Language:	Inglês
Published:	2014
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5547996/ https://ncbi.nlm.nih.gov/pubmed/25088202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.239
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WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis

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