Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is caused by the cooperation of multiple oncogenic lesions(1,2). We used exome sequencing on 67 T-ALLs to gain insight into the mutational spectrum in these leukemias. We detected protein-altering mutations in 508 genes, with an average of 8.2 mutations in...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Keersmaecker, Kim De, Atak, Zeynep Kalender, Li, Ning, Vicente, Carmen, Patchett, Stephanie, Girardi, Tiziana, Gianfelici, Valentina, Geerdens, Ellen, Clappier, Emmanuelle, Porcu, Michaël, Lahortiga, Idoya, Lucà, Rossella, Yan, Jiekun, Hulselmans, Gert, Vranckx, Hilde, Vandepoel, Roel, Sweron, Bram, Jacobs, Kris, Mentens, Nicole, Wlodarska, Iwona, Cauwelier, Barbara, Cloos, Jacqueline, Soulier, Jean, Uyttebroeck, Anne, Bagni, Claudia, Hassan, Bassem A, Vandenberghe, Peter, Johnson, Arlen W, Aerts, Stein, Cools, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547913/
https://ncbi.nlm.nih.gov/pubmed/23263491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2508
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