BRCT-domain protein BRIT1 influences class switch recombination

DNA double-strand breaks (DSBs) serve as obligatory intermediates for Ig heavy chain (Igh) class switch recombination (CSR). The mechanisms by which DSBs are resolved to promote long-range DNA end-joining while suppressing genomic instability inherently associated with DSBs are yet to be fully eluci...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Yen, Wei-Feng, Chaudhry, Ashutosh, Vaidyanathan, Bharat, Yewdell, William T., Pucella, Joseph N., Sharma, Rahul, Liang, Yulong, Li, Kaiyi, Rudensky, Alexander Y., Chaudhuri, Jayanta
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547652/
https://ncbi.nlm.nih.gov/pubmed/28724724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708211114
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