Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements

Unfolded states of proteins and native states of intrinsically disordered proteins (IDPs) populate heterogeneous conformational ensembles in solution. The average sizes of these heterogeneous systems, quantified by the radius of gyration (R(G)), can be measured by small-angle X-ray scattering (SAXS)...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Fuertes, Gustavo, Banterle, Niccolò, Ruff, Kiersten M., Chowdhury, Aritra, Mercadante, Davide, Koehler, Christine, Kachala, Michael, Estrada Girona, Gemma, Milles, Sigrid, Mishra, Ankur, Onck, Patrick R., Gräter, Frauke, Esteban-Martín, Santiago, Pappu, Rohit V., Svergun, Dmitri I., Lemke, Edward A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547626/
https://ncbi.nlm.nih.gov/pubmed/28716919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704692114
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