Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements

Unfolded states of proteins and native states of intrinsically disordered proteins (IDPs) populate heterogeneous conformational ensembles in solution. The average sizes of these heterogeneous systems, quantified by the radius of gyration (R(G)), can be measured by small-angle X-ray scattering (SAXS)...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Fuertes, Gustavo, Banterle, Niccolò, Ruff, Kiersten M., Chowdhury, Aritra, Mercadante, Davide, Koehler, Christine, Kachala, Michael, Estrada Girona, Gemma, Milles, Sigrid, Mishra, Ankur, Onck, Patrick R., Gräter, Frauke, Esteban-Martín, Santiago, Pappu, Rohit V., Svergun, Dmitri I., Lemke, Edward A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547626/
https://ncbi.nlm.nih.gov/pubmed/28716919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704692114
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