Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements

Unfolded states of proteins and native states of intrinsically disordered proteins (IDPs) populate heterogeneous conformational ensembles in solution. The average sizes of these heterogeneous systems, quantified by the radius of gyration (R(G)), can be measured by small-angle X-ray scattering (SAXS)...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Fuertes, Gustavo, Banterle, Niccolò, Ruff, Kiersten M., Chowdhury, Aritra, Mercadante, Davide, Koehler, Christine, Kachala, Michael, Estrada Girona, Gemma, Milles, Sigrid, Mishra, Ankur, Onck, Patrick R., Gräter, Frauke, Esteban-Martín, Santiago, Pappu, Rohit V., Svergun, Dmitri I., Lemke, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547626/
https://ncbi.nlm.nih.gov/pubmed/28716919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704692114
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