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Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy

McArdle disease and mitochondrial myopathy impair muscle oxidative phosphorylation (OXPHOS) by distinct mechanisms: the former by restricting oxidative substrate availability caused by blocked glycogen breakdown, the latter because of intrinsic respiratory chain defects. We applied metabolic profili...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Delaney, Nigel F., Sharma, Rohit, Tadvalkar, Laura, Clish, Clary B., Haller, Ronald G., Mootha, Vamsi K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547614/
https://ncbi.nlm.nih.gov/pubmed/28716914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703338114
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