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stageR: a general stage-wise method for controlling the gene-level false discovery rate in differential expression and differential transcript usage

RNA sequencing studies with complex designs and transcript-resolution analyses involve multiple hypotheses per gene; however, conventional approaches fail to control the false discovery rate (FDR) at gene level. We propose stageR, a two-stage testing paradigm that leverages the increased power of ag...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genome Biol
Egile Nagusiak: Van den Berge, Koen, Soneson, Charlotte, Robinson, Mark D., Clement, Lieven
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547545/
https://ncbi.nlm.nih.gov/pubmed/28784146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1277-0
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