ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells

Management of infection with hepatitis B virus (HBV) remains a global health problem. Persistence of stable covalently closed circular DNA (cccDNA) during HBV replication is responsible for modest curative efficacy of currently licensed drugs. Novel gene editing technologies, such as those based on...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Scott, Tristan, Moyo, Buhle, Nicholson, Samantha, Maepa, Mohube Betty, Watashi, Koichi, Ely, Abdullah, Weinberg, Marc S., Arbuthnot, Patrick
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547162/
https://ncbi.nlm.nih.gov/pubmed/28785016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07642-6
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