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Synergistic antipruritic effects of GABA-A and GABA-B agonists in a mouse model of atopic dermatitis

BACKGROUND: Despite recent insights into the pathophysiology of acute and chronic itch, chronic itch remains an often intractable condition. Among major contributors to chronic itch is dysfunction of spinal cord GABAergic inhibitory controls. OBJECTIVE: To test the hypothesis that selective GABA ago...

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Publicado en:J Allergy Clin Immunol
Main Authors: Cevikbas, Ferda, Braz, Joao M, Wang, Xidao, Solorzano, Carlos, Sulk, Mathias, Buhl, Timo, Steinhoff, Martin, Basbaum, Allan I
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546982/
https://ncbi.nlm.nih.gov/pubmed/28232084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.02.001
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