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Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation
To better understand smoking cessation, we examined the actions of varenicline (Chantix) during long-term nicotine exposure. Varenicline reduced nicotine upregulation of α4β2-type nicotinic receptors (α4β2Rs) in live cells and neurons, but not for membrane preparations. Effects on upregulation depen...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5546804/ https://ncbi.nlm.nih.gov/pubmed/28718768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25651 |
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