Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

BACKGROUND: Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several Onchocerca volvu...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Negl Trop Dis
Auteurs principaux: Doyle, Stephen R., Bourguinat, Catherine, Nana-Djeunga, Hugues C., Kengne-Ouafo, Jonas A., Pion, Sébastien D. S., Bopda, Jean, Kamgno, Joseph, Wanji, Samuel, Che, Hua, Kuesel, Annette C., Walker, Martin, Basáñez, Maria-Gloria, Boakye, Daniel A., Osei-Atweneboana, Mike Y., Boussinesq, Michel, Prichard, Roger K., Grant, Warwick N.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546710/
https://ncbi.nlm.nih.gov/pubmed/28746337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005816
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