New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity

Interleukin-15 (IL-15) is a potent cytokine that increases CD8(+) T and NK cell numbers and function in experimental models. However, obstacles remain in using IL-15 therapeutically, specifically its low potency and short in vivo half-life. To help overcome this, a new IL-15 superagonist complex com...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bailey, Cavan P., Budak-Alpdogan, Tulin, Sauter, Christopher T., Panis, Michelle M., Buyukgoz, Cihangir, Jeng, Emily K., Wong, Hing C., Flomenberg, Neal, Alpdogan, Onder
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546486/
https://ncbi.nlm.nih.gov/pubmed/28574833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17875
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