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Loss of hepatic mitochondrial long chain fatty acid oxidation confers resistance to diet-induced obesity and glucose intolerance

The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for systemic metabolic adaptations such as gluconeogenesis and ketogenesis. To understand the role of hepatic fatty acid oxidation in response to a chronic high fat diet (HFD), we generated mice with a liver-s...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Lee, Jieun, Choi, Joseph, Selen Alpergin, Ebru S., Zhao, Liang, Hartung, Thomas, Scafidi, Susanna, Riddle, Ryan C., Wolfgang, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546239/
https://ncbi.nlm.nih.gov/pubmed/28723568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.06.080
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