Paucimannose-Rich N-glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions

Human neutrophil elastase (HNE) is an important N-glycosylated serine protease in the innate immune system, but the structure and immune-modulating functions of HNE N-glycosylation remain undescribed. Herein, LC-MS/MS-based glycan, glycopeptide and glycoprotein profiling were utilized to first deter...

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Publicat a:Mol Cell Proteomics
Autors principals: Loke, Ian, Østergaard, Ole, Heegaard, Niels H. H., Packer, Nicolle H., Thaysen-Andersen, Morten
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546201/
https://ncbi.nlm.nih.gov/pubmed/28630087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.066746
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