Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa Opioid Agonist with Enhanced Metabolic Stability

Previous structure-activity studies on the neoclerodane diterpenoid salvinorin A have demonstrated the importance of the acetoxy functionality on the A-ring in its activity as a kappa opioid receptor agonist. Few studies have focused on understanding the role of conformation in these interactions. H...

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Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Sherwood, Alexander M., Crowley, Rachel Saylor, Paton, Kelly F., Biggerstaff, Andrew, Neuenswander, Benjamin, Day, Victor W., Kivell, Bronwyn M., Prisinzano, Thomas E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546011/
https://ncbi.nlm.nih.gov/pubmed/28376298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00148
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