PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer

Increased abundance of the prostate-specific membrane antigen (PSMA) on prostate epithelium is a hallmark of advanced metastatic prostate cancer (PCa) and correlates negatively with prognosis. However, direct evidence that PSMA functionally contributes to PCa progression remains elusive. We generate...

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Vydáno v:Sci Signal
Hlavní autoři: Caromile, Leslie Ann, Dortche, Kristina, Rahman, M. Mamunur, Grant, Christina L., Stoddard, Christopher, Ferrer, Fernando A., Shapiro, Linda H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545931/
https://ncbi.nlm.nih.gov/pubmed/28292957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aag3326
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