Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex

Bifunctional polynuclear platinum compounds represent a novel class of metal-based antitumor drugs which are currently undergoing preclinical development. A typical agent is [{trans-PtCl(NH(3))(2)}(2)H(2)N(CH(2))(4)NH(2)]Cl(2) (1,1/t,t), which coordinates to bases in DNA and forms various types of c...

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Bibliografiset tiedot

Julkaisussa:	Nucleic Acids Res
Päätekijät:	Hofr, Ctirad, Farrell, Nicholas, Brabec, Viktor
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Oxford University Press 2001
Aiheet:	Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.10.2034
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