Antidepressant responsiveness in adulthood is permanently impaired after neonatal destruction of the neurogenic pool

The dynamic turnover of hippocampal neurons is implicated in the regulation of cognitive and affective behavior. Extending our previous demonstration that administration of dexamethasone (ND) to neonatal rats depletes the resident population of neural precursor cells (NPC) and restrains the size of...

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Publicado en:Transl Psychiatry
Autores principales: Yu, S, Zutshi, I, Stoffel, R, Zhang, J, Ventura-Silva, A P, Sousa, N, Costa, P S, Holsboer, F, Patchev, A, Almeida, O F X
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545723/
https://ncbi.nlm.nih.gov/pubmed/28045461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2016.255
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