Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

The major energy source for most cells is glucose, from which ATP is generated via glycolysis and/or oxidative metabolism. Glucose deprivation activates AMP-activated protein kinase (AMPK)1, but it has been unclear whether this occurs solely via changes in AMP or ADP, the classical activators of AMP...

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Pubblicato in:Nature
Autori principali: Zhang, Chen-Song, Hawley, Simon A., Zong, Yue, Li, Mengqi, Wang, Zhichao, Gray, Alexander, Ma, Teng, Cui, Jiwen, Feng, Jin-Wei, Zhu, Mingjiang, Wu, Yu-Qing, Li, Terytty Yang, Ye, Zhiyun, Lin, Shu-Yong, Yin, Huiyong, Piao, Hai-Long, Hardie, D. Grahame, Lin, Sheng-Cai
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544942/
https://ncbi.nlm.nih.gov/pubmed/28723898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23275
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