Disruption of the Aldehyde Dehydrogenase 2 Gene Results in No Increase in Trabecular Bone Mass Due to Skeletal Loading in Association with Impaired Cell Cycle Regulation Through p21 Expression in the Bone Marrow Cells of Mice

Approximately 45% of people of East Asian descent have the inactive aldehyde dehydrogenase 2 (ALDH2) phenotype. The enzyme defect of ALDH2 has been found to adversely influence the risk of osteoporosis. The aim of this study was to clarify the effect of skeletal loading on trabecular bone structure...

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Detalhes bibliográficos
Publicado no:Calcif Tissue Int
Main Authors: Okuma, Kayoko Furukawa, Menuki, Kunitaka, Tsukamoto, Manabu, Tajima, Takafumi, Fukuda, Hokuto, Okada, Yasuaki, Mori, Toshiharu, Tsuchiya, Takuto, Kawamoto, Toshihiro, Yoshida, Yasuhiro, Uchida, Soshi, Sakai, Akinori
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544803/
https://ncbi.nlm.nih.gov/pubmed/28474171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-017-0285-0
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