Disruption of the Aldehyde Dehydrogenase 2 Gene Results in No Increase in Trabecular Bone Mass Due to Skeletal Loading in Association with Impaired Cell Cycle Regulation Through p21 Expression in the Bone Marrow Cells of Mice

Approximately 45% of people of East Asian descent have the inactive aldehyde dehydrogenase 2 (ALDH2) phenotype. The enzyme defect of ALDH2 has been found to adversely influence the risk of osteoporosis. The aim of this study was to clarify the effect of skeletal loading on trabecular bone structure...

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Dettagli Bibliografici
Pubblicato in:Calcif Tissue Int
Autori principali: Okuma, Kayoko Furukawa, Menuki, Kunitaka, Tsukamoto, Manabu, Tajima, Takafumi, Fukuda, Hokuto, Okada, Yasuaki, Mori, Toshiharu, Tsuchiya, Takuto, Kawamoto, Toshihiro, Yoshida, Yasuhiro, Uchida, Soshi, Sakai, Akinori
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2017
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544803/
https://ncbi.nlm.nih.gov/pubmed/28474171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-017-0285-0
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