Incoming nucleotide binds to Klenow ternary complex leading to stable physical sequestration of preceding dNTP on DNA

Klenow–DNA complex is known to undergo a rate-limiting, protein conformational transition from an ‘open’ to ‘closed’ state, upon binding of the ‘correct’ dNTP at the active site. In the ‘closed’ state, Mg(2+) mediates a rapid chemical step involving nucleophilic displacement of pyrophosphate by the...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Ramanathan, Sunita, Chary, K. V. R., Rao, Basuthkar J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55446/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353079/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.10.2097
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