Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity

Endometrial carcinoma (EC) exhibits the strongest association with obesity of all cancers. Growth of these tumors is driven by PI3K/AKT activation, and opposed by tumor suppressors, including the tuberous sclerosis complex 2 (TSC-2) and p27, with inactivation of TSC2 and loss or cytoplasmic mislocal...

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Publicat a:Curr Mol Med
Autors principals: McCampbell, Adrienne S., Mittelstadt, Megan L., Dere, Ruhee, Kim, Sunam, Zhou, Lijun, Djordjevic, Bojana, Soliman, Pamela T., Zhang, Qian, Wei, Caimiao, Hursting, Stephen D., Lu, Karen H., Broaddus, Russell R., Walker, Cheryl Lyn
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544384/
https://ncbi.nlm.nih.gov/pubmed/26917264
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