Fast and accurate HLA typing from short-read next-generation sequence data with xHLA

The HLA gene complex on human chromosome 6 is one of the most polymorphic regions in the human genome and contributes in large part to the diversity of the immune system. Accurate typing of HLA genes with short-read sequencing data has historically been difficult due to the sequence similarity betwe...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Xie, Chao, Yeo, Zhen Xuan, Wong, Marie, Piper, Jason, Long, Tao, Kirkness, Ewen F., Biggs, William H., Bloom, Ken, Spellman, Stephen, Vierra-Green, Cynthia, Brady, Colleen, Scheuermann, Richard H., Telenti, Amalio, Howard, Sally, Brewerton, Suzanne, Turpaz, Yaron, Venter, J. Craig
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544337/
https://ncbi.nlm.nih.gov/pubmed/28674023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707945114
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