Antibody-induced uncoating of human rhinovirus B14

Rhinoviruses (RVs) are the major causes of common colds in humans. They have a nonenveloped, icosahedral capsid surrounding a positive-strand RNA genome. Here we report that the antigen-binding (Fab) fragment of a neutralizing antibody (C5) can trigger genome release from RV-B14 to form emptied part...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Dong, Yangchao, Liu, Yue, Jiang, Wen, Smith, Thomas J., Xu, Zhikai, Rossmann, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544331/
https://ncbi.nlm.nih.gov/pubmed/28696310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707369114
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