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Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels
Sensory hair cells rely on otoferlin as the calcium sensor for exocytosis and encoding of sound preferentially over the neuronal calcium sensor synaptotagmin. Although it is established that synaptotagmin cannot rescue the otoferlin KO phenotype, the large size and low solubility of otoferlin have p...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5544299/ https://ncbi.nlm.nih.gov/pubmed/28696301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703240114 |
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