An attenuated Shigella mutant lacking the RNA-binding protein Hfq provides cross-protection against Shigella strains of broad serotype

Few live attenuated vaccines protect against multiple serotypes of bacterial pathogen because host serotype-specific immune responses are limited to the serotype present in the vaccine strain. Here, immunization with a mutant of Shigella flexneri 2a protected guinea pigs against subsequent infection...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Mitobe, Jiro, Sinha, Ritam, Mitra, Soma, Nag, Dhrubajyoti, Saito, Noriko, Shimuta, Ken, Koizumi, Nobuo, Koley, Hemanta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544247/
https://ncbi.nlm.nih.gov/pubmed/28727722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005728
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