Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer

PTX3 is a component of the humoral arm of innate immunity and an extrinsic oncosuppressor gene taming tumor-promoting inflammation. Here, we show that two enhancers differently regulate PTX3 expression: enhancer 1, located 230 kb upstream of PTX3 promoter, mediated the action of inflammatory transcr...

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Détails bibliographiques
Publié dans:Oncoimmunology
Auteurs principaux: Rubino, Marcello, Kunderfranco, Paolo, Basso, Gianluca, Greco, Carolina Magdalen, Pasqualini, Fabio, Serio, Simone, Roncalli, Massimo, Laghi, Luigi, Mantovani, Alberto, Papait, Roberto, Garlanda, Cecilia
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543905/
https://ncbi.nlm.nih.gov/pubmed/28811977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1333215
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