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Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and decreased proliferation. Together these changes mitigate the negative impact of oxygen dep...
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| Publicado no: | J Exp Clin Cancer Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5543535/ https://ncbi.nlm.nih.gov/pubmed/28774341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0570-9 |
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