Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase

[Image: see text] Triosephosphate isomerase (TIM) is a proficient catalyst of the reversible isomerization of dihydroxyacetone phosphate (DHAP) to d-glyceraldehyde phosphate (GAP), via general base catalysis by E165. Historically, this enzyme has been an extremely important model system for understa...

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Publicado en:J Am Chem Soc
Autores principales: Kulkarni, Yashraj S., Liao, Qinghua, Petrović, Dušan, Krüger, Dennis M., Strodel, Birgit, Amyes, Tina L., Richard, John P., Kamerlin, Shina C. L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2017
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543394/
https://ncbi.nlm.nih.gov/pubmed/28683550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05576
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