Mutations Driving Airborne Transmission of A/H5N1 Virus in Mammals Cause Substantial Attenuation in Chickens only when combined

A/H5N1 influenza viruses pose a threat to human and animal health. A fully avian A/H5N1 influenza virus was previously shown to acquire airborne transmissibility between ferrets upon accumulation of five or six substitutions that affected three traits: polymerase activity, hemagglutinin stability an...

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Udgivet i:Sci Rep
Main Authors: Richard, Mathilde, Herfst, Sander, van den Brand, Judith M. A., de Meulder, Dennis, Lexmond, Pascal, Bestebroer, Theo M., Fouchier, Ron A. M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543172/
https://ncbi.nlm.nih.gov/pubmed/28775271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07000-6
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