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Mucosal vaccination with pili from Group A Streptococcus expressed on Lactococcus lactis generates protective immune responses

The human pathogen Group A Streptococcus (GAS) produces pili that are involved in adhesion and colonisation of the host. These surface-exposed pili are immunogenic and therefore represent an attractive target for vaccine development. The pilus is encoded in the genomic region known as the fibronecti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Loh, Jacelyn M. S., Lorenz, Natalie, Tsai, Catherine J.-Y., Khemlani, Adrina Hema J., Proft, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543120/
https://ncbi.nlm.nih.gov/pubmed/28775292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07602-0
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