Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

Therapies targeting signaling molecules mutated in cancers can often have striking short-term effects, but the emergence of resistant cancer cells is a major barrier to full cures(1,2). Resistance can result from a secondary mutations(3,4), but other times there is no clear genetic cause, raising th...

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Vydáno v:Nature
Hlavní autoři: Shaffer, Sydney M., Dunagin, Margaret C., Torborg, Stefan R., Torre, Eduardo A., Emert, Benjamin, Krepler, Clemens, Beqiri, Marilda, Sproesser, Katrin, Brafford, Patricia A., Xiao, Min, Eggan, Elliott, Anastopoulos, Ioannis N., Vargas-Garcia, Cesar A., Singh, Abhyudai, Nathanson, Katherine L., Herlyn, Meenhard, Raj, Arjun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542814/
https://ncbi.nlm.nih.gov/pubmed/28607484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22794
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