Maternal obesity programs reduced leptin signaling in the pituitary and altered GH/IGF1 axis function leading to increased adiposity in adult sheep offspring

Studies in rodents highlight a role for leptin in stimulation of pituitary growth hormone (GH) secretion, with an impact on body composition regulation. We have reported that maternal obesity (MO) during ovine pregnancy results in hyperphagia, glucose-insulin dysregulation, increased adiposity, hype...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tuersunjiang, Nuermaimaiti, Odhiambo, John F., Shasa, Desiree R., Smith, Ashley M., Nathanielsz, Peter W., Ford, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542597/
https://ncbi.nlm.nih.gov/pubmed/28771488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181795
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