Maternal obesity programs reduced leptin signaling in the pituitary and altered GH/IGF1 axis function leading to increased adiposity in adult sheep offspring

Studies in rodents highlight a role for leptin in stimulation of pituitary growth hormone (GH) secretion, with an impact on body composition regulation. We have reported that maternal obesity (MO) during ovine pregnancy results in hyperphagia, glucose-insulin dysregulation, increased adiposity, hype...

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Publicat a:PLoS One
Autors principals: Tuersunjiang, Nuermaimaiti, Odhiambo, John F., Shasa, Desiree R., Smith, Ashley M., Nathanielsz, Peter W., Ford, Stephen P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542597/
https://ncbi.nlm.nih.gov/pubmed/28771488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181795
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