Ectromelia virus accumulates less double-stranded RNA compared to vaccinia virus in BS-C-1 cells

Most orthopoxviruses, including vaccinia virus (VACV), contain genes in the E3L and K3L families. The protein products of these genes have been shown to combat PKR, a host defense pathway. Interestingly, ectromelia virus (ECTV) contains an E3L ortholog but does not possess an intact K3L gene. Here,...

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Gepubliceerd in:Virology
Hoofdauteurs: Frey, Tiffany R., Lehmann, Michael H., Ryan, Colton M., Pizzorno, Marie C., Sutter, Gerd, Hersperger, Adam R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541908/
https://ncbi.nlm.nih.gov/pubmed/28628829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.06.010
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