Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells

BACKGROUND: In humans, the heterochronic cascade composed of the RNA-binding protein LIN28 and its major target, the let-7 family of microRNAs (miRNAs), is highly regulated during human erythroid ontogeny. Additionally, down-regulation of the let-7 miRNAs in cultured adult CD34(+) cells or the over-...

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Bibliographic Details
Published in:J Transl Med
Main Authors: de Vasconcellos, Jaira F., Byrnes, Colleen, Lee, Y. Terry, Allwardt, Joshua M., Kaushal, Megha, Rabel, Antoinette, Miller, Jeffery L.
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541688/
https://ncbi.nlm.nih.gov/pubmed/28768505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1273-x
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