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Site-specific in vivo bioorthogonal ligation via chemical modulation

A critical limitation of bioorthogonal click chemistry for in vivo applications has been its low reaction efficiency due to the pharmacokinetic barriers, such as blood distribution, circulation, and elimination in living organisms. To identify key factors that dominate the efficiency of click chemis...

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Bibliographic Details
Published in:Adv Healthc Mater
Main Authors: Koo, Heebeom, Lee, Jeong Heon, Bao, Kai, Wu, Yunshan, Fakhri, Georges El, Henary, Maged, Yun, Seok Hyun, Choi, Hak Soo, Park, G.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541365/
https://ncbi.nlm.nih.gov/pubmed/27568818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201600574
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