Laboratory Evolution of a Biotin-Requiring Saccharomyces cerevisiae Strain for Full Biotin Prototrophy and Identification of Causal Mutations

Biotin prototrophy is a rare, incompletely understood, and industrially relevant characteristic of Saccharomyces cerevisiae strains. The genome of the haploid laboratory strain CEN.PK113-7D contains a full complement of biotin biosynthesis genes, but its growth in biotin-free synthetic medium is ext...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Bracher, Jasmine M., de Hulster, Erik, Koster, Charlotte C., van den Broek, Marcel, Daran, Jean-Marc G., van Maris, Antonius J. A., Pronk, Jack T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541218/
https://ncbi.nlm.nih.gov/pubmed/28600311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00892-17
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