Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3

Type 2 diabetes (T2D) and insulin resistance are associated with reduced glucose utilization in the muscle and poor exercise performance. Here we find that depletion of an epigenome modifier, histone deacetylase 3 (HDAC3), specifically in skeletal muscle causes severe systemic insulin resistance in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Hong, Sungguan, Zhou, Wenjun, Fang, Bin, Lu, Wenyun, Loro, Emanuele, Damle, Manashree, Ding, Guolian, Jager, Jennifer, Zhang, Sisi, Zhang, Yuxiang, Feng, Dan, Chu, Qingwei, Dill, Brian D, Molina, Henrik, Khurana, Tejvir S, Rabinowitz, Joshua D, Lazar, Mitchell A, Sun, Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540654/
https://ncbi.nlm.nih.gov/pubmed/27991918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4245
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados