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DNA mutation motifs in the genes associated with inherited diseases

Mutations in human genes can be responsible for inherited genetic disorders and cancer. Mutations can arise due to environmental factors or spontaneously. It has been shown that certain DNA sequences are more prone to mutate. These sites are termed hotspots and exhibit a higher mutation frequency th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Růžička, Michal, Kulhánek, Petr, Radová, Lenka, Čechová, Andrea, Špačková, Naďa, Fajkusová, Lenka, Réblová, Kamila
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540541/
https://ncbi.nlm.nih.gov/pubmed/28767725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182377
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