Zinc Regulates Chemical Transmitter Storage in Nanometer Vesicles and Exocytosis Dynamics Measured by Amperometry

We applied electrochemical techniques with nano-tip electrodes to show that micromolar concentrations of zinc not only trigger changes in the dynamics of exocytosis, but also vesicle content in a model cell line. The vesicle catecholamine content in PC12 cells is significantly decreased after 100 μM...

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Udgivet i:Angew Chem Int Ed Engl
Main Authors: Ren, Lin, Pour, Masoumeh Dowlatshahi, Majdi, Soodabeh, Li, Xianchan, Malmberg, Per, Ewing, Andrew G
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540326/
https://ncbi.nlm.nih.gov/pubmed/28319311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201700095
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