B. abortus RNA is the component involved in the down-modulation of MHC-I expression on human monocytes via TLR8 and the EGFR pathway

Despite eliciting a potent CD8(+) T cell response, Brucella abortus is able to persist and establish a chronic infection inside its host. We have previously reported that the infection of human monocytes/macrophages with B. abortus inhibits the IFN-γ-induced MHC-I cell surface expression down-modula...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Milillo, M. Ayelén, Velásquez, Lis N., Trotta, Aldana, Delpino, M. Victoria, Marinho, Fábio V., Balboa, Luciana, Vermeulen, Mónica, Espindola, Sonia L., Rodriguez-Rodrigues, Nahuel, Fernández, Gabriela C., Oliveira, Sergio Costa, Giambartolomei, Guillermo H., Barrionuevo, Paula
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540288/
https://ncbi.nlm.nih.gov/pubmed/28767704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006527
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